Fifteen-minute consultation: Pharmacogenomics: a guide for busy clinicians.
Christopher Mark ParryDaniel HawcuttPublished in: Archives of disease in childhood. Education and practice edition (2019)
The ultimate goal of pharmacogenomics is to understand how the effects of interindividual genetic variation impact on the response of patients to treatments and in turn optimise those treatments while minimising potential side effects. This review article provides a brief overview of pharmacogenomics, focusing on the methods used to understand how genes of interest are identified, how pharmacogenomics is currently used within paediatric clinical practice within the UK, potential areas for future use and some of the caveats specific to paediatric medicine.
Keyphrases
- adverse drug
- clinical decision support
- clinical practice
- end stage renal disease
- intensive care unit
- emergency department
- palliative care
- newly diagnosed
- ejection fraction
- chronic kidney disease
- prognostic factors
- human health
- current status
- gene expression
- sensitive detection
- fluorescent probe
- risk assessment
- genome wide identification
- quantum dots