A novel dual epigenetic approach targeting BET proteins and HDACs in Group 3 (MYC-driven) Medulloblastoma.

Matthew J KlingVarun KesherwaniNitish K MishraGracey AlexanderErin M McIntyreSutapa RayKishore B ChallagundlaShantaram S JoshiDon W CoulterNagendra K Chaturvedi

Published in: Journal of experimental & clinical cancer research : CR (2022)

Together, our findings demonstrated that dual-inhibition of BET and HDAC proteins of the epigenetic pathway can be a novel therapeutic approach against MYC-driven MB.

Keyphrases

dna methylation
gene expression
transcription factor
cancer therapy