Comparison of the Time to Extubation and Length of Stay in the PACU after Sugammadex and Neostigmine Use in Two Types of Surgery: A Monocentric Retrospective Analysis.
Cyrus MotamedJean Louis BourgainPublished in: Journal of clinical medicine (2021)
Sugammadex provides a rapid pharmacological reversal of aminosteroid, as well as fewer pulmonary complications, a better physiological recovery, and shorter stays in the postanesthetic recovery unit (PACU). This retrospective analysis of our Centricity anesthesia database in 2017-2019 assessed the efficiency of sugammadex in real-life situations in two groups of surgical cancer patients (breast and abdominal surgery) based on the extubation time, operating room exit time, and length of PACU stay. Overall, 382 anesthesia records (131 breast and 251 abdominal surgeries) were extracted for the pharmacological reversal of neuromuscular blockades by neostigmine or sugammadex. Sugammadex was used for reversal in 91 breast and 204 abdominal surgeries. Sugammadex use did not affect the extubation time, operating room exit time, or length of PACU stay. However, the time to reach a 90% train of four (TOF) recovery was significantly faster in sugammadex patients: 2 min (1.5-8) in breast surgery and 2 min (1.5-7) in abdominal surgery versus 10 (6-20) and 9 min (5-20), respectively, for neostigmine (p < 0.05). Most patients who were reversed with sugammadex (91%) reached a TOF ratio of at least 90%, while 54% of neostigmine patients had a 90% TOF ratio recorded (p < 0.05). Factors other than pharmacological reversal probably influence the extubation time, operating room exit time, or PACU stay; however, sugammadex reliably shortened the time so as to reach a 90% TOF ratio with a better level of reversal.
Keyphrases
- mass spectrometry
- end stage renal disease
- ms ms
- cardiac surgery
- chronic kidney disease
- minimally invasive
- newly diagnosed
- mechanical ventilation
- ejection fraction
- coronary artery bypass
- peritoneal dialysis
- coronary artery disease
- pulmonary hypertension
- emergency department
- respiratory failure
- intensive care unit
- acute respiratory distress syndrome
- high speed
- patient reported
- extracorporeal membrane oxygenation
- loop mediated isothermal amplification