Protective Effect of Qiliqiangxin against Doxorubicin-Induced Cardiomyopathy by Suppressing Excessive Autophagy and Apoptosis.

Yating Qin Chao Lv Xinxin Zhang Weibin Ruan Xiangyu Xu Chen Chen Xiaoning Wan Xinyun Ji Juan Zhou Li Lu Xiaomei Guo

Published in: Cardiovascular therapeutics (2022)

QL exhibited protective roles against DOX-induced cardiotoxicity possibly via mediating the PI3K/AKT/mTOR pathway, leading to inhibition of autophagy and subsequent apoptosis activities.

Keyphrases

endoplasmic reticulum stress
oxidative stress
cell death
diabetic rats
high glucose
cell cycle arrest
signaling pathway
heart failure
drug induced
drug delivery
endothelial cells
cell proliferation
weight loss