Development of a three-dimensional in vitro co-culture model to increase drug selectivity for humans.

Sung Bum ParkByumseok KohWon Hoon JungKyoung Jin ChoiYoon Ju NaHee Min YooSunray LeeDukjin KangDong-Mok LeeKi Young Kim

Published in: Diabetes, obesity & metabolism (2020)

Our 3D co-culture model with/without 3D co-culture plates can successfully mimic insulin resistance while allowing investigation of the effects of anti-obesity or anti-diabetic drugs on human or mouse co-culturing cell type. This 3D co-culture system may accelerate screening of drugs for insulin resistance depending on species.

Keyphrases

insulin resistance
type diabetes
metabolic syndrome
adipose tissue
high fat diet induced
high fat diet
skeletal muscle
polycystic ovary syndrome
endothelial cells
weight loss
drug induced
emergency department
wound healing
induced pluripotent stem cells
weight gain
body mass index
genetic diversity