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Gamma-tocopherol ameliorates hyperglycemia-induced hepatic inflammation associated with NLRP3 inflammasome in alloxan-induced diabetic mice.

Heaji LeeYunsook Lim
Published in: Nutrition research and practice (2019)
The findings suggested that GT supplementation ameliorated hepatic damage by attenuating inflammation and oxidative stress in alloxan-induced diabetic mice. Taken together, GT could be a beneficial nutrient that can ameliorate inflammatory responses associated with NLRP3 inflammasome in hyperglycemia-induced hepatic damage.
Keyphrases
  • oxidative stress
  • diabetic rats
  • nlrp inflammasome
  • high glucose
  • endothelial cells
  • ischemia reperfusion injury
  • induced apoptosis
  • mouse model