MicroRNAs in Axial Spondylarthritis: an Overview of the Recent Progresses in the Field with a Focus on Ankylosing Spondylitis and Psoriatic Arthritis.
Francesca MottaAndrea PederzaniMaria Cristina CarenaAngela CeribelliPaul B WordsworthMaria De SantisCarlo SelmiMatteo VecellioPublished in: Current rheumatology reports (2021)
AS and PsA are chronic inflammatory musculoskeletal diseases with axial manifestations and represent an excellent model for studying microRNAs contribution to the disease pathogenesis, particularly through immunomodulation, inflammation, and bone remodelling, or their value as candidate diagnostic and prognostic biomarkers. MicroRNAs are single-stranded nucleotides able to regulate gene expression. They are a key component of the epigenetic machinery, involved in physiological and pathological processes. The contribution of microRNAs in AS and PsA (such as miR-29a in regulating bone metabolism) is highlighted by several works in the field but their utility as possible markers must be still confirmed, particularly in larger patients' cohorts.
Keyphrases
- ankylosing spondylitis
- gene expression
- prostate cancer
- end stage renal disease
- dna methylation
- oxidative stress
- bone mineral density
- ejection fraction
- chronic kidney disease
- newly diagnosed
- cell proliferation
- rheumatoid arthritis
- peritoneal dialysis
- disease activity
- long non coding rna
- radical prostatectomy
- soft tissue
- bone loss
- bone regeneration
- binding protein
- long noncoding rna
- patient reported outcomes