Crosstalk between m 6 A regulators and mRNA during cancer progression.

m 6 A modification, the most abundant and widespread RNA modification, is present and involved in the occurrence and development of various cancers. To date, most studies have mainly focused on the roles of a single m 6 A regulator (writer/eraser/reader) in various cancers, but cumulative evidence shows that aberrant m 6 A regulators and m 6 A levels exert dual effects (promoting and/or inhibiting roles) in cancer progression. Recently, studies have investigated the direct interactions between different m 6 A regulators (writer/eraser and reader) and mRNAs in a variety of cancers. In this review, we summarize the functions of m 6 A regulators and their roles in various types of cancers. We further propose the possible crosstalk mechanisms (Writer-m 6 A-Reader-mRNA axis and Eraser-m 6 A-Reader-mRNA axis) between different m 6 A regulators and mRNAs during cancer progression. We also discuss the clinical potential of m 6 A regulator‑targeting strategies.