Association of the hOCT1/ABCB1 genotype with efficacy and tolerability of imatinib in patients affected by chronic myeloid leukemia.

Laura GaleottiFrancesco CeccheriniDario DomingoMarco LaurinoMarialuisa PolilloAntonello Di PaoloClaudia BaratèCarmen FavaAntonio D'AvolioGiulia CervettiFrancesca GuerriniGiulia FontanelliElena CiabattiSusanna GrassiElena ArrigoniRomano DanesiMario PetriniFulvio CornoltiGiuseppe SaglioSara Galimberti

Published in: Cancer chemotherapy and pharmacology (2017)

The novelty of this study is dual: the achievement of results that potentially have a significant clinical interest and the demonstration that the adoption of composed covariates may represent a unique tool to study different aspects of the treatment with imatinib.

Keyphrases

chronic myeloid leukemia
end stage renal disease
ejection fraction
newly diagnosed
open label
peritoneal dialysis
patient reported outcomes