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PD-L1 expression, CD8+ and CD4+ lymphocyte rate are predictive of pathological complete response after neoadjuvant chemoradiotherapy for squamous cell cancer of the thoracic esophagus.

Matteo FassanFrancesco CavallinVincenza GuzzardoAndromachi KotsaftiMelania ScarpaMatteo CagolVanna Chiarion-SileniLuca Maria SaadehRita AlfieriIgnazio CastagliuoloMassimo RuggeCarlo CastoroMelania Scarpa
Published in: Cancer medicine (2019)
PD-L1 expression and CD8+ and CD4+ lymphocyte rate were predictive of ypCR after neoadjuvant CTRT for SCC of the thoracic esophagus with adequate accuracy. Furthermore, recurrence/relapse was associated with high level of CD4+ T cell infiltration. However, the small sample size prevented to draw definitive conclusions; further studies are necessary to evaluate the prognostic role of these markers.
Keyphrases
  • squamous cell
  • locally advanced
  • rectal cancer
  • spinal cord
  • lymph node
  • nk cells
  • squamous cell carcinoma
  • peripheral blood
  • radiation therapy