YAP/TAZ Suppress Drug Penetration Into Hepatocellular Carcinoma Through Stromal Activation.

Kyungjoo ChoSimon Weonsang RoHye Won LeeHyuk MoonSojung HanHye Rim KimSang Hoon AhnJun Yong ParkDo Young Kim

Published in: Hepatology (Baltimore, Md.) (2021)

Drug delivery into liver cancer is impaired by YAP/TAZ signaling in tumor cells and subsequent activation of stroma by the signaling. Disrupting or targeting activated tumor stroma might improve drug delivery into HCC with an elevated YAP/TAZ activity.

Keyphrases

drug delivery
cancer therapy
bone marrow
drug induced
electronic health record