Progress of Pretreatment and Analytical Methods of Proton Pump Inhibitors: An Update since 2010.
De-Mei SunZhang YuanYu ZhouXue-Song FengXin-Yuan ZhangPublished in: Critical reviews in analytical chemistry (2023)
Proton pump inhibitors (PPIs) are the most commonly used medication for stomach secretion disorders. However, when it comes to safe, discreet pharmaceutical practice, widely recognized preparational and analytical method(s) for PPIs with sensitivity, selectivity, speed and high accuracy still remains underdeveloped. For this reason, this paper sets out to make a comprehensive review of the preparation and determination methods for PPIs based on multiple matrices since 2010. We have integrated newly-developed techniques (such as solid phase extraction, liquid phase micro-extraction, and solid phase micro-extraction) into conventional sample preparational methods. On the other hand, our analytical techniques include liquid chromatography, supercritical fluid chromatography, capillary electrophoresis, and employment of sensors. In addition, we have identified the pros and cons of each technique and have forecast their future developmental trends.
Keyphrases
- liquid chromatography
- solid phase extraction
- mass spectrometry
- capillary electrophoresis
- tandem mass spectrometry
- molecularly imprinted
- high resolution mass spectrometry
- high performance liquid chromatography
- liquid chromatography tandem mass spectrometry
- ultra high performance liquid chromatography
- simultaneous determination
- gas chromatography mass spectrometry
- gas chromatography
- healthcare
- primary care
- emergency department
- ionic liquid
- high speed
- ms ms