Nebivolol elicits a neuroprotective effect in the cuprizone model of multiple sclerosis in mice: emphasis on M1/M2 polarization and inhibition of NLRP3 inflammasome activation.

Antoinette G NaeemReem N El-NagaHaidy E Michel

Published in: Inflammopharmacology (2022)

These findings suggest the potential neuroprotective effect of Neb in the Cup-induced model of MS in mice, at least partially by virtue of shifting microglia towards M2 phenotype, mitigation of NLRP3 inflammasome activation and alleviation of oxidative stress.

Keyphrases

nlrp inflammasome
multiple sclerosis
oxidative stress
diabetic rats
high fat diet induced
inflammatory response
ms ms
high glucose
dna damage
white matter
neuropathic pain
spinal cord
brain injury