Tumor microenvironment gene expression profiles associated to complete pathological response and disease progression in resectable NSCLC patients treated with neoadjuvant chemoimmunotherapy.
Marta CasarrubiosMariano Provencio PullaErnest NadalAmelia InsaMaría Del Rosario García-CampeloMartín LázaroManuel DómineMargarita Majem TarruellaDelvys Rodriguez AbreuAlex Martinez-MartiJavier De Castro CarpeñoManuel CoboGuillermo López-VivancoElvira Del BarcoReyes BernabéNuria ViñolasIsidoro Barneto ArandaBartomeu MassutiBelén Sierra-RoderoCristina Martinez-ToledoIsmael Fernández-MirandaRoberto Serna-BlancoAtocha RomeroVirginia CalvoAlberto Cruz-BermúdezPublished in: Journal for immunotherapy of cancer (2022)
Our results reinforce the differences between CPR and non-CPR responses, describing possible response and relapse immune mechanisms, opening the possibility of therapy personalization of immunotherapy-based regimens in the neoadjuvant setting of NSCLC.