Tumor microenvironment gene expression profiles associated to complete pathological response and disease progression in resectable NSCLC patients treated with neoadjuvant chemoimmunotherapy.

Marta Casarrubios Mariano Provencio Pulla Ernest Nadal Amelia Insa María Del Rosario García-Campelo Martín Lázaro Manuel Dómine Margarita Majem Tarruella Delvys Rodríguez-Abreu Alex Martinez-Marti Javier De Castro Carpeño Manuel Cobo Guillermo López-Vivanco Elvira Del Barco Reyes Bernabé Nuria Viñolas Isidoro Barneto Aranda Bartomeu Massuti Belén Sierra-Rodero Cristina Martinez-Toledo Ismael Fernández-Miranda Roberto Serna-Blanco Atocha Romero Virginia Calvo Alberto Cruz-Bermúdez

Published in: Journal for immunotherapy of cancer (2022)

Our results reinforce the differences between CPR and non-CPR responses, describing possible response and relapse immune mechanisms, opening the possibility of therapy personalization of immunotherapy-based regimens in the neoadjuvant setting of NSCLC.

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