Knockdown of CDC20 promotes adipogenesis of bone marrow-derived stem cells by modulating β-catenin.

Yangge DuYunsong LiuYongsheng ZhouYongsheng Zhou

Published in: Stem cell research & therapy (2022)

Our findings showed that CDC20 knockdown enhanced adipogenesis of hBMSC and mBMSCs adipogenesis in vitro and in vivo. CDC20 regulates both adipogenesis and osteogenesis of BMSCs, and might lead to the development of new therapeutic targets for "fatty bone" and osteoporosis.

Keyphrases

stem cells
high fat diet induced
cell cycle
bone mineral density
cell proliferation
postmenopausal women
signaling pathway
epithelial mesenchymal transition
mesenchymal stem cells
insulin resistance
type diabetes
bone marrow
body composition
skeletal muscle