Insulin resistance negatively affects bone quality not quantity: the relationship between bone and adipose tissue.

I M de AraújoL T Parreiras-E-SilvaA L CarvalhoJ EliasC E G SalmonFrancisco José Albuquerque Paula

Published in: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA (2020)

The present study shows that the trabecular bone score is negatively associated with marrow adipose tissue, insulin resistance, visceral adipose tissue and intrahepatic lipid measurements. Additionally, there was a negative relationship between saturated lipids in marrow adipose tissue and the trabecular bone score. These results encourage further studies to investigate the role of the trabecular bone score exam in the clinical evaluation of osteoporosis in conditions of insulin resistance.

Keyphrases

adipose tissue
insulin resistance
bone mineral density
postmenopausal women
high fat diet
body composition
polycystic ovary syndrome
metabolic syndrome
skeletal muscle
soft tissue
high fat diet induced
bone loss
bone regeneration