Serum metabolomics analysis reveals metabolite profile and key biomarkers of idiopathic membranous nephropathy.

Mingjun YeDonge TangWeilong LiChiyu MaZhipeng ZengShengyou LiaoZhuoheng SongYu MengFanna LiuShaodong LuanLianghong YinYong Dai

Published in: PeerJ (2023)

Our study revealed the profiles of DEMs from the IMN and HC groups. The result demonstrated that there were disorders of amino acids, nucleotides, and steroids hormones metabolism in IMN patients. The down-regulation of DHEAS may be associated with the imbalance of the immune environment in IMN patients. In host-microbiome origin analysis, the gut microbiota and metabolite disturbances were present in IMN patients.

Keyphrases

end stage renal disease
newly diagnosed
ejection fraction
peritoneal dialysis
prognostic factors
mass spectrometry
amino acid
single cell
data analysis