Platelet releasate promotes skeletal myogenesis by increasing muscle stem cell commitment to differentiation and accelerates muscle regeneration following acute injury.

David ScullyPeggy SfyriSandrine VerpoortenPetros PapadopoulosMaría Carmen Muñoz-TurrillasRobert MitchellAhmed AburimaKetan PatelLaura GutiérrezKhalid M NaseemAntonios Matsakas

Published in: Acta physiologica (Oxford, England) (2018)

This study provides novel mechanistic insights on the role of platelet releasate in skeletal myogenesis and set the physiological basis for exploiting platelets as biomaterials in regenerative medicine.

Keyphrases

stem cells
skeletal muscle
liver failure
respiratory failure
intensive care unit
mesenchymal stem cells
cell therapy
hepatitis b virus
extracorporeal membrane oxygenation
bone regeneration