This de-identified case study seeks to increase the understanding of the process and impact of modifying exposure and response prevention (ERP) to address obsessions associated with COVID-19. The case study presents the assessment, diagnosis, and treatment of obsessive-compulsive disorder via televideo utilizing ERP for a woman who presented with difficulty with contamination and harm obsessions related to COVID-19. Over the course of 7 months, including an initial evaluation, this client attended 24 treatment sessions via synchronous video telehealth. Psychoeducation, self-monitoring, in vivo and imaginal exposures, response prevention, and behavioral activation strategies were utilized. Following treatment, this client was successfully managing symptoms and her scores on the Yale Brown Obsessive-Compulsive Scale and Sheehan Disability Scale had decreased significantly.