α-Hederin Increases The Apoptosis Of Cisplatin-Resistant Gastric Cancer Cells By Activating Mitochondrial Pathway In Vivo And Vitro.

Yinghui LiuHongbo LeiJingjing MaHuan DengPengzhan HeWeiguo Dong

Published in: OncoTargets and therapy (2019)

Our study provides strong molecular evidence to support our hypothesis that α-hederin inhibits the proliferation and induces the apoptosis of HGC27/DDP cells by increasing the levels of intracellular ROS and triggering mitochondrial pathway activation.

Keyphrases

cell cycle arrest
oxidative stress
cell death
induced apoptosis
pi k akt
signaling pathway
endoplasmic reticulum stress
dna damage
reactive oxygen species
single molecule