Management and Pharmacological Treatment of Peripheral Arterial Disease.
Samantha J LeathamKarl R WinckelKeshia R De GuzmanPublished in: Journal of pharmacy practice (2024)
Background: Peripheral arterial disease (PAD) is a complex, heterogeneous condition that has become a leading health concern globally. Peripheral arterial disease often co-exists with other vascular disease states, including cerebrovascular and cardiovascular disease. Optimal therapy for managing symptoms and progression of disease employs non-pharmacological, pharmacological, and contemporary revascularisation techniques to improve clinical outcomes and quality of life. However, large well-designed randomised control trials (RCT) and corresponding evidence-based guidelines for management of PAD are lacking, with current practice standards often extrapolated from evidence in coronary artery disease. Purpose: This review article aims to discuss currently accepted best pharmacological practice for PAD. Method: Relevant articles were searched between May 2023 and January 2024 through PubMed, Cochrane Library, Google Scholar and international guidelines, focusing on pharmacological management for PAD. Results: This narrative review discusses holistic pharmacological treatments for PAD.
Keyphrases
- cardiovascular disease
- coronary artery disease
- healthcare
- primary care
- public health
- clinical trial
- heart failure
- type diabetes
- clinical practice
- cardiovascular events
- percutaneous coronary intervention
- risk assessment
- open label
- physical activity
- climate change
- quality improvement
- acute coronary syndrome
- depressive symptoms
- health information
- transcatheter aortic valve replacement
- ejection fraction
- aortic stenosis