Small-molecule Polθ inhibitors provide safe and effective tumor radiosensitization in preclinical models.

Gonzalo Rodriguez-Berriguete Marco Ranzani Remko Prevo Rathi Puliyadi Nicole D Machado Hannah R Bolland Val Millar Daniel V Ebner Marie Boursier Aurora Cerutti Alessandro Cicconi Alessandro Galbiati Diego Grande Vera Grinkevich Jayesh Majithiya Desiree Piscitello Eeson Rajendra Martin Stockley Simon J Boulton Eva-Leonne Göttgens Robert A Heald Graeme C M Smith Helen Robinson Geoff S Higgins

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)

These results pave the way for future clinical trials of Polθ inhibitors in combination with radiotherapy.

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