PIK3CA hotspot mutations p. H1047R and p. H1047L sensitize breast cancer cells to thymoquinone treatment by regulating the PI3K/Akt1 pathway.

Ju ZhouSaber ImaniMarzieh Dehghan ShasaltanehShuguang LiuTao LuJunjiang Fu

Published in: Molecular biology reports (2021)

These two PIK3CA hotspot mutations therefore not only contribute to tumor progression in patients with MBC but may also serve as targets for the development of novel small molecule therapeutic strategies.

Keyphrases

small molecule
breast cancer cells
protein kinase
protein protein
long non coding rna
replacement therapy