Effectiveness and Safety of Direct Oral Anticoagulants versus Warfarin in Obese Patients with Acute Venous Thromboembolism.
James C CoonsLauren AlbertAndrea BejjaniCarlo J IasellaPublished in: Pharmacotherapy (2020)
To our knowledge, this is the largest clinical study to date showing that patients with obesity can be treated effectively and safely with a DOAC compared with warfarin for acute VTE. Thus DOACs should be considered a reasonable alternative to warfarin for treatment of acute VTE in obese patients.
Keyphrases
- direct oral anticoagulants
- venous thromboembolism
- obese patients
- bariatric surgery
- liver failure
- weight loss
- respiratory failure
- metabolic syndrome
- roux en y gastric bypass
- gastric bypass
- type diabetes
- drug induced
- aortic dissection
- insulin resistance
- healthcare
- adipose tissue
- weight gain
- clinical trial
- skeletal muscle
- extracorporeal membrane oxygenation
- mechanical ventilation
- double blind
- replacement therapy