Al18F-labeled alpha-melanocyte-stimulating hormone (α-MSH) peptide derivative for the early detection of melanoma.

Citra R A P PalangkaHirofumi HanaokaAiko YamaguchiTakashi MurakamiYoshito Tsushima

Published in: Annals of nuclear medicine (2019)

We successfully prepared Al18F-NOTA-GGNle-CycMSHhex in a simple and efficient manner. Al18F-NOTA-GGNle-CycMSHhex showed high tumor accumulation and clearly visualized very small tumors in melanoma-bearing mice. These findings suggest that Al18F-NOTA-GGNle-CycMSHhex will be a promising PET tracer for melanoma imaging at an earlier stage.

Keyphrases

skin cancer
positron emission tomography
computed tomography
type diabetes
pet ct
photodynamic therapy
fluorescence imaging