Multiple molecular interactions redundantly contribute to RB-mediated cell cycle control.
Michael J ThwaitesMatthew J CecchiniSrikanth TalluriDaniel T PassosJasmyne CarnevaleFrederick A DickPublished in: Cell division (2017)
Our work demonstrates that pRB utilizes a network of mechanisms to prevent cell cycle entry. This has important implications for the use of new CDK4/6 inhibitors that aim to activate this proliferative control network.
Keyphrases