Undetectable anti-Mullerian hormone and inhibin B do not preclude the presence of germ cell tumours in 45,X/46,XY or 46,XY gonadal dysgenesis.
Sabine Elisabeth HannemaKatja P WolffenbuttelYolande van BeverHennie T BruggenwirthSjoerd A A van den BergRemko HersmusJ Wolter OosterhuisLeendert H J LooijengaPublished in: Clinical endocrinology (2023)
Undetectable serum AMH and inhibin B cannot reliably predict the absence of germ cells and germ cell tumours in individuals with 45,X/46,XY or 46,XY gonadal dysgenesis. This information should help in counselling about prophylactic gonadectomy, taking into account both the germ cell cancer risk and potential for gonadal function. This article is protected by copyright. All rights reserved.