Results of surgical ventricular reconstruction in a specialized center and in comparison to the STICH trial: Rationale and study protocol for a patient-level pooled analysis.
Mario F L GaudinoSerenella CastelvecchioMohamed RahoumaN Bryce RobinsonKatia AudisioGiovanni Jr SolettiAndrea GarattiUmberto BenedettoLeonard N GirardLorenzo MenicantiPublished in: Journal of cardiac surgery (2021)
Individual data of patients who underwent SVR with or without CABG will be obtained from San Donato University Hospital in Milan. Using multivariable Cox regression analysis, significant prognostic indicators in this cohort will be identified. We will then compare the San Donato cohort to individual patient's data from the SVR arm of Hypothesis 2 of the STICH trial and from both arms of the STICH Extended Study (STICHES). To reduce confounders, propensity score adjustment will be used for this comparison. The primary endpoint will be all-cause mortality. Data will be merged and analyzed independently at Weill Cornell Medicine in New York.
Keyphrases
- electronic health record
- clinical trial
- end stage renal disease
- newly diagnosed
- case report
- study protocol
- phase iii
- ejection fraction
- heart failure
- phase ii
- palliative care
- peritoneal dialysis
- data analysis
- deep learning
- patient reported outcomes
- percutaneous coronary intervention
- clinical evaluation
- coronary artery bypass