DRP1 inhibition-mediated mitochondrial elongation abolishes cancer stemness, enhances glutaminolysis, and drives ferroptosis in oral squamous cell carcinoma.

Zhen WangShouyi TangLuyao CaiQing WangDan PanYunmei DongHao ZhouJing LiNing JiXin ZengYu ZhouYing-Qiang ShenQianming Chen

Published in: British journal of cancer (2024)

Our study reveals a novel mechanism underlying mitochondrial dynamics mediated cancer stemness acquisition and highlights the therapeutic potential of mitochondria elongation to increase the susceptibility of cancer cells to ferroptosis.

Keyphrases

papillary thyroid
cell death
stem cells
oxidative stress
squamous cell
epithelial mesenchymal transition
squamous cell carcinoma
childhood cancer
young adults
reactive oxygen species
endoplasmic reticulum