Whole genome bisulfite sequencing of human spermatozoa reveals differentially methylated patterns from type 2 diabetic patients.

Xiongfeng ChenQinghua LinJunping WenWei LinJixing LiangHuibin HuangLiantao LiJianxin HuangFalin ChenDeli LiuGang Chen

Published in: Journal of diabetes investigation (2020)

Our study provides the first evidence for deoxyribonucleic acid methylation reprogramming in spermatozoa of type 2 diabetes mellitus patients, and provides a new basis for explaining the complex mechanism of type 2 diabetes mellitus susceptibility in offspring.

Keyphrases

end stage renal disease
endothelial cells
newly diagnosed
ejection fraction
chronic kidney disease
peritoneal dialysis
genome wide
gene expression
skeletal muscle
insulin resistance