Frequency of germline pathogenic variants in breast cancer predisposition genes among young Turkish breast cancer patients.
Aysun Dauti IsiklarLamiya AliyevaAhmet YesilyurtAykut SoyderGül BaşaranPublished in: Breast cancer research and treatment (2023)
One fifth of Turkish breast cancer patients ≤ 40 years of age had at least one PV/LPV in breast cancer predisposing genes with 26-gene inherited cancer panel. The frequency of PV/LPVs was higher in triple-negative young-onset patients compared to hormone receptor and Her-2 positive subtypes. Our findings regarding to frequency PV/LPVs in BRCA 1/2 and non-BRCA genes in young-onset breast cancer patients are in line with the literature.
Keyphrases
- genome wide
- genome wide identification
- end stage renal disease
- copy number
- middle aged
- bioinformatics analysis
- breast cancer risk
- genome wide analysis
- ejection fraction
- newly diagnosed
- systematic review
- chronic kidney disease
- papillary thyroid
- transcription factor
- dna methylation
- prognostic factors
- gene expression
- squamous cell
- patient reported outcomes
- young adults
- childhood cancer
- patient reported
- lymph node metastasis