Wolbachia -mediated resistance to Zika virus infection in Aedes aegypti is dominated by diverse transcriptional regulation and weak evolutionary pressures.
Emma C BoehmAnna S JaegerHunter J RiesDavid CastañedaAndrea M WeilerCorina C ValenciaJames Weger-LucarelliGregory D EbelShelby L O ConnorThomas C FriedrichMostafa ZamanianMatthew T AliotaPublished in: bioRxiv : the preprint server for biology (2023)
exerts detectable selective pressures on ZIKV in coinfected mosquitoes. Together our data suggest that it may be difficult for ZIKV to evolve Wolbachia resistance, perhaps due to the complexity of the pathogen blockade mechanism.