Environmental Determinants of Coronavirus Disease 2019 (COVID-19).
Eric B BrandtTesfaye B MershaPublished in: Current allergy and asthma reports (2021)
In this review, we provide a critical assessment of COVID-19 risk factors, identify gaps in our knowledge (e.g., indoor air pollution), and discuss methodological challenges of association and causation and the impact lockdowns had on air quality. In addition, we will draw attention to ethnic and socioeconomic factors driving viral transmission related to COVID-19. The complex role angiotensin-converting enzyme 2 (ACE2) plays in COVID-19 and future promising avenues of research are discussed. To demonstrate causality, we stress the need for future epidemiologic studies integrating personal air pollution exposures, detailed clinical COVID-19 data, and a range of socioeconomic factors, as well as in vitro and in vivo mechanistic studies.
Keyphrases
- coronavirus disease
- air pollution
- sars cov
- angiotensin converting enzyme
- respiratory syndrome coronavirus
- risk factors
- particulate matter
- healthcare
- current status
- risk assessment
- artificial intelligence
- electronic health record
- chronic obstructive pulmonary disease
- working memory
- data analysis
- heat stress
- case control
- health risk
- deep learning
- adverse drug