Salivary cortisol and cortisone in diagnosis of Cushing's syndrome - a comparison of six different analytical methods.

Nils BäcklundGöran BrattsandStaffan LundstedtElisabeth AardalInga BartusevicieneKatarina BerinderCharlotte HöybyePia BurmanBritt Edén EngströmAnders IsakssonAnders BlomgrenOskar RagnarssonUlrika RüetschiJeanette WahlbergTommy OlssonPer Dahlqvist

Published in: Clinical chemistry and laboratory medicine (2023)

We present robust reference intervals for salivary cortisol and cortisone at 08:00 h, 23:00 h and 08:00 h after DST for several clinically used methods. The similarities between LC-MS/MS methods allows for direct comparison of absolute values. Diagnostic accuracy for CS was high for all salivary cortisol and cortisone LC-MS/MS methods and salivary cortisol IAs evaluated.

Keyphrases

mass spectrometry
clinical evaluation