Subcortical short-term plasticity elicited by deep brain stimulation.
Mohammad Z AwadRyan J VadenZachary T IrwinChristopher L GonzalezSarah BlackArie NakhmaniByron C JaegerJ Nicole BentleyBarton L GuthrieHarrison C WalkerPublished in: Annals of clinical and translational neurology (2021)
Paired DBS pulses synchronize local circuit electrophysiology and elicit short-term neuroplasticity in the subthalamic-pallidal circuit. Collectively, these responses likely represent the earliest detectable interaction between the DBS pulse and local neuronal tissue in humans. Evoked subcortical field potentials could serve as a predictive biomarker to guide the implementation of next-generation directional and adaptive stimulation devices.