From "wet" matrices to "dry" blood spot sampling strategy: a versatile LC-MS/MS assay for simultaneous monitoring caffeine and its three primary metabolites in preterm infants.

Hao-Ran DaiHong-Li GuoWei-Jun WangXian ShenRui ChengJing XuYa-Hui HuXuan-Sheng DingFeng Chen

Published in: Clinical chemistry and laboratory medicine (2023)

A versatile LC-MS/MS platform for simultaneous monitoring caffeine and its three primary metabolites was developed, fully validated, and successfully applied into the routine clinical TDM practices. Sampling method switching from "wet" matrices to "dry" DBS will facilitate and support the precision dosing of caffeine for preterm infants.

Keyphrases

preterm infants
low birth weight
ms ms
high throughput
healthcare
primary care
clinical practice