Ortho-Topolin Riboside Induced Differentiation through Inhibition of STAT3 Signaling in Acute Myeloid Leukemia HL-60 Cells

Li Wang Jiao Cheng FanLin Lin ShengXian Liu Hui Pan MingDa Li ShanShan Li Na Li Weiping Li

Published in: Turkish journal of haematology : official journal of Turkish Society of Haematology (2019)

Collectively, our data indicate a differentiation-induced mechanism underlying the inhibition of STAT3 signaling upon treatment with oTR. Therefore, oTR may constitute a novel differentiation-induced therapeutic for use in clinical treatment of AML.

Keyphrases

high glucose
diabetic rats
drug induced
acute myeloid leukemia
oxidative stress
endothelial cells
electronic health record
acute lymphoblastic leukemia
big data
cell cycle arrest
replacement therapy