A Joint Model for Vitamin K-Dependent Clotting Factors and Anticoagulation Proteins.

Qing-Xi OoiDaniel F B WrightR Campbell TaitGeoffrey K IsbisterStephen B Duffull

Published in: Clinical pharmacokinetics (2018)

The joint model represents the first work to quantify the influence of warfarin on all six VK-dependent coagulation proteins simultaneously. Future work will expand the model to predict the influence of exogenously administered VK on the time course of clotting factor concentrations after warfarin overdose and during perioperative warfarin reversal procedures.

Keyphrases

atrial fibrillation
venous thromboembolism
direct oral anticoagulants
patients undergoing
cardiac surgery