Neural defects caused by total and Wnt1-Cre mediated ablation of p120ctn in mice.
Tim PietersEllen SandersHuiyu TianJolanda van HengelFrans van RoyPublished in: BMC developmental biology (2020)
These results indicate that p120ctn is required for neurogenesis and neurulation. Elimination of p120ctn in cells expressing Wnt1 affects neural tube closure by hampering correct formation of specific adhesion and actomyosin complexes at the apical side of neural folds. Collectively, our results demonstrate the crucial role of p120ctn during brain morphogenesis.
Keyphrases
- stem cells
- cell proliferation
- induced apoptosis
- cerebral ischemia
- cell cycle arrest
- type diabetes
- multiple sclerosis
- escherichia coli
- staphylococcus aureus
- cell death
- signaling pathway
- high fat diet induced
- resting state
- skeletal muscle
- metabolic syndrome
- atrial fibrillation
- radiofrequency ablation
- endoplasmic reticulum stress
- subarachnoid hemorrhage
- cystic fibrosis
- blood brain barrier
- catheter ablation