Rosuvastatin exerts anti-atherosclerotic effects by improving macrophage-related foam cell formation and polarization conversion via mediating autophagic activities.
Xinxin ZhangYating QinXiaoning WanHao LiuChao LvWeibin RuanLin HeLi LuXiaomei GuoPublished in: Journal of translational medicine (2021)
Our study indicated that RVS exhibits atheroprotective effects involving regulation lipid accumulation and polarization conversion by improving autophagy initiation and development via suppressing PI3K/Akt/mTOR axis and enhancing autophagic flux in macrophages.
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