Cell membrane-anchored and tumor-targeted IL-12 (attIL12)-T cell therapy for eliminating large and heterogeneous solid tumors.
Jiemiao HuQing YangWendong ZhangHongwei DuYuhui ChenQingnan ZhaoLong DaoXueqing XiaFowlkes Natalie WallZhongting ZhangKris MahadeoRichard GorlickS KopetzGianpietro DottiShulin LiPublished in: Journal for immunotherapy of cancer (2022)
This novel approach sheds light on the safe application of IL-12-based T-cell therapy for large and heterogeneous solid tumors.
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