Creatine supplementation in Walker-256 tumor-bearing rats prevents skeletal muscle atrophy by attenuating systemic inflammation and protein degradation signaling.
Paola S CellaPoliana C MarinelloFernando H BorgesDiogo F RibeiroPatrícia ChiminMayra T J TestaPhilippe B GuirroJosé A DuarteRubens CecchiniFlávia A GuarnierRafael DeminicePublished in: European journal of nutrition (2019)
Creatine supplementation prevents skeletal muscle atrophy by attenuating tumor-induced pro-inflammatory environment, a condition that minimizes Atrogin-1 and MuRF-1-dependent proteolysis.