A multiscale modeling study of particle size effects on the tissue penetration efficacy of drug-delivery nanoparticles.
Mohammad Aminul IslamSutapa BaruaDipak BaruaPublished in: BMC systems biology (2017)
Our work suggests that the size of a nanoparticle may play a less significant role in its ability to overcome the intra-tissue transport barriers. We show that experiments involving cell-free tissue systems may yield misleading observations of particle size effects due to the absence of advective transport and particle-cell interactions.