Comparison of a thymine challenge test and endogenous uracil-dihydrouracil levels for assessment of fluoropyrimidine toxicity risk.

Kathryn Elisa Burns Ottiniel Chavani Soo Hee JeongJohn A DuleyDavid Porter Michael P N Findlay Robert Matthew Strother Nuala Ann Helsby

Published in: Cancer chemotherapy and pharmacology (2021)

The endogenous uracil-based parameters, adjusted to CrCL, were more predictive of increased risk of severe fluoropyrimidine toxicity than DPYD genotyping. However, endogenous U measurement detected fewer cases of severe toxicity than the THY challenge test.

Keyphrases

oxidative stress
early onset
high throughput
oxide nanoparticles
gene expression
drug induced
dna methylation
breast cancer risk