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Homozygous Hypomorphic HNF1A Alleles Are a Novel Cause of Young-Onset Diabetes and Result in Sulfonylurea-Sensitive Diabetes.

Shivani MisraNeelam HassanaliAmanda J BennettAgata JuszczakRichard CaswellKevin ColcloughJonathan ValabhjiSian EllardNicholas S OliverAnna L Gloyn
Published in: Diabetes care (2020)
Homozygous hypomorphic HNF1A variants are a cause of HNF1A-MODY. We thus expand the allelic spectrum of variants in dominant genes causing diabetes.
Keyphrases
  • type diabetes
  • cardiovascular disease
  • glycemic control
  • copy number
  • nuclear factor
  • genome wide
  • toll like receptor
  • insulin resistance
  • transcription factor
  • inflammatory response
  • adipose tissue