Piperine Alters the Pharmacokinetics and Anticoagulation of Warfarin in Rats.

Aref L ZayedWahby M BabareshRuba S DarweeshTamam El-ElimatSahar S Hawamdeh

Published in: Journal of experimental pharmacology (2020)

We conclude that piperine could be a potent inhibitor of cytochrome P450 metabolism of warfarin in vivo and, contrary to the expectation, may reduce the plasma concentration and anticoagulation of warfarin. This interaction could have a clinical significance and should be investigated in patients.

Keyphrases

atrial fibrillation
venous thromboembolism
direct oral anticoagulants
end stage renal disease
oral anticoagulants
newly diagnosed
chronic kidney disease
ejection fraction
prognostic factors
peritoneal dialysis
patient reported outcomes
atomic force microscopy
anti inflammatory