Vitamin K antagonist anticoagulant usage is associated with increased incidence and progression of osteoarthritis.
Cindy Germaine BoerIngrid SzilagyiN Long NguyenTuhina NeogiIngrid MeulenbeltM Arfan IkramAndré G UitterlindenSita Bierma-ZeinstraBruno H StrickerJoyce B van MeursPublished in: Annals of the rheumatic diseases (2021)
These findings support the importance of vitamin K and vitamin K-dependent proteins, as MGP, in the pathogenesis of OA. Additionally, these results may have direct implications for the clinical prevention of OA, supporting the consideration of direct oral anticoagulants in favour of VKAs.