Type 2 Diabetes Partitioned Polygenic Scores Associate With Disease Outcomes in 454,193 Individuals Across 13 Cohorts.
Daniel DiCorpoJessica LeClairJoanne B ColeChloé SarnowskiAnke H Maitland-van der ZeeLawrence F BielakAnneke BlokstraErwin P BottingerLayal ChakerYii-Der I ChenYe ChenPaul S de VriesTariq FaquihMohsen GhanbariValborg GudmundsdottirXiuqing GuoNatalie R HasbaniDorina IbiM Arfan IkramMaryam KavousiHampton L LeonardAaron LeongJosep Maria MercaderAlanna C MorrisonGirish Nitin NadkarniMike A NallsRaymond NoordamMichael PreussJennifer A SmithStella TrompetPetra VissinkJie YaoWei ZhaoEric BoerwinkleMark O GoodarziVilmundur G GudnasonJ Wouter JukemaSharon L R KardiaRuth J F LoosChing-Ti LiuAlisa K ManningDennis Mook-KanamoriJames S PankowH Susan J PicavetNaveed SattarEleanor M SimonsickW M Monique VerschurenKo Willems van DijkJose C FlorezJerome I RotterJames B MeigsJosée DupuisMiriam S UdlerPublished in: Diabetes care (2022)
Our findings support that genetically driven pathways leading to T2D also predispose differentially to clinical outcomes.