Smooth Muscle Mineralocorticoid Receptor Promotes Hypertension After Preeclampsia.
Lauren A BiwerQing LuJaime IbarrolaAlec StepanianJoshua J ManBrigett V CarvajalNicholas D CamardaZsuzsanna K ZsengellerGeraldine SkurnikEllen W SeelyS Ananth KarumanchiIris Z JaffePublished in: Circulation research (2023)
These data support that sFlt1-induced vascular injury during PE produces a persistent state of enhanced sensitivity of SMC-MR to activation. This contributes to postpartum hypertension in response to common stresses and supports testing of MR antagonism to mitigate the increased cardiovascular risk in women after PE.
Keyphrases
- smooth muscle
- blood pressure
- pregnancy outcomes
- contrast enhanced
- magnetic resonance
- polycystic ovary syndrome
- high glucose
- diabetic rats
- early onset
- electronic health record
- big data
- drug induced
- computed tomography
- oxidative stress
- pregnant women
- machine learning
- adipose tissue
- skeletal muscle
- binding protein
- deep learning
- data analysis
- breast cancer risk
- artificial intelligence
- stress induced