The influence of obesity-related factors in the etiology of renal cell carcinoma-A mendelian randomization study.
Mattias JohanssonRobert Carreras-TorresGhislaine SceloMark P PurdueDaniela MariosaDavid C MullerNicholas John TimpsonPhilip C HaycockKevin K BrownZhaoming WangYuanqing YeJonathan N HofmannMatthieu FollValerie GaborieauMitchell J MachielaLeandro M ColliPeng LiJean-Guillaume GarnierHelene BlancheAnne BolandLaurie BurdetteEgor ProkhortchoukKonstantin G SkryabinMeredith YeagerSanja Radojevic-SkodricSimona OgnjanovicLenka ForetovaIvana HolcatovaVladimir JanoutDana MatesAnush MukeriyaStefan RascuDavid ZaridzeVladimir BenckoCezary CybulskiEleonora FabianovaViorel JingaJolanta LissowskaJan LubinskiMarie NavratilovaPeter RudnaiSimone BenhamouGeraldine Cancel-TassinOlivier CussenotElisabete WeiderpassBörje LjungbergRaviprakash Tumkur SitaramChristel HäggströmFiona Jane BruinsmaSusan J JordanGianluca SeveriIngrid M WinshipKristian HveemLars J VattenTony FletcherSusanna C LarssonAlicja WolkRosamonde E BanksPeter J SelbyDouglas F EastonGabriella AndreottiLaura E Beane-FreemanStella KoutrosSatu MännistöStephanie J WeinsteinPeter E ClarkTodd L EdwardsLoren LipworthSusan M GapsturVictoria L StevensHallie A CarolMatthew L FreedmanMark M PomerantzEunyoung ChoKathryn M WilsonJ Michael GazianoHoward D SessoNeal D FreedmanAlexander S ParkerJeanette E Eckel-PassowWen-Yi HuangRichard J KahnoskiBrian R LaneSabrina L NoyesDavid PetilloBin Tean TehUlrike PetersEmily WhiteGarnet L AndersonLisa JohnsonJuhua LuoJulie BuringI-Min LeeWong-Ho ChowLee E MooreTimothy EisenMarc Yves Romain HenrionJames LarkinPoulami BarmanBradley C LeibovichToni K ChoueiriG Mark LathropJean-Francois DeleuzeMarc GunterJames D McKayXifeng WuRichard S HoulstonStephen J ChanockCaroline ReltonJohn Brent RichardsRichard M MartinGeorge Davey SmithPaul J BrennanPublished in: PLoS medicine (2019)
This study provides novel evidence for an etiological role of insulin in RCC, as well as confirmatory evidence that obesity and DBP influence RCC risk.